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Process Development - Group Leader at Jobs in Science

Process Development - Group Leader

Jobs in Science Little Walden, Essex, Essex Full-Time
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Lead the Process Development group in the preclinical development of novel medicines comprising a consortium of live bacteria delivered orally to the intestinal tract. The successful candidate will actively contribute to the Company’s development programmes in ulcerative colitis and immune-oncology. The successful candidate will be responsible for in-house fermentation process development for multiple anaerobic gut bacteria that comprise the medicine, characterising and optimising their growth and providing support for upstream and downstream method development and optimisation.

Responsibilities:

* Leading a small team to develop fermentation processes to produce live bacterial therapeutics comprising multiple bacterial strains

* Performing anaerobic fermentation of bacteria from deep well blocks to small fermenters

* Developing media screens and optimising media for growth of metabolically diverse bacteria

* Co-ordinating outsourced lyophilisation development studies and developing an in-house capability for lyophilisation development.

* Working closely with the assay development team to develop suitable assays to assess microbial cell quality

* Maintaining an awareness of latest technologies and equipment for incorporation into company labs

* Ensuring detailed records of experiments are kept within the team, suitable for supporting regulatory filings.

* Supporting process transfer to CDMOs

Candidate Specifications:

Essential requirements for this post include:

* PhD in relevant discipline eg: Microbiology or Bioprocess Engineering with focus on fermentation.

* In-depth bacteriology knowledge

* Post-doctoral experience in a bioprocess development environment utilising fermentation technology

* Experience of optimising manufacturing processes and methodologies.

* Strong leadership skills (Preferable experience of leading small teams).

* Demonstrable initiative

* Excellent communication and interpersonal skills.

Desirable requirements for this post include:

* Experience of using Design of Experiments (DOE)

* Previous experience working with a microbiome therapeutic or probiotic development company

* Expertise in handling and culturing anaerobic bacteria

* Experience of developing processes for subsequent application in GMP manufacture

* Experience of process technology transfer to external companies

* Experience of lyophilisation process development
 

Recommended skills

Microbiology
Bioprocess
Bioprocess Engineering
Probiotic
Bacteria Cultures
Anaerobic Organisms
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Job ID: 212171550